In vitro killing effect of moxifloxacin on clinical isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole.
Giamarellos-Bourboulis EJ, Karnesis L, Galani I, Giamarellou H.
4th Department of Internal Medicine, Medical School, University of Athens, Greece. giamarel@internet.gr
The time-kill effect of moxifloxacin on 20 genetically distinct isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole was studied. The majority (80%) were killed by a concentration equivalent to four times the MIC; the MIC induced a transient decrease in bacterial counts at 4 h, followed by regrowth. No effect was detected in four isolates. These results merit further clinical consideration.
PMID: 12435710 [PubMed - indexed for MEDLINE]PMCID: PMC132774