Case report
A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-γ
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* Corresponding author: Kamiar Zomorodian zomorodian@razi.tums.ac.ir
1 Department of Infectious Diseases, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Medical Mycology & Parasitology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Immunology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
Annals of Clinical Microbiology and Antimicrobials 2005, 4:4 doi:10.1186/1476-0711-4-4
Published: 3 March 2005Abstract
Background
Chronic granulomatous disease (CGD) is a rare disorder of phagocytes in which absence of superoxide and hydrogen peroxide production in phagocytes predisposes patients to bacterial and fungal infections. The most common fungal infections in these patients are caused by Aspergillus species.
Case presentation
Here, we describe Aspergillus osteomyelitis of the ribs and hepatic abscess in a 5-year-old boy. The patient was successfully treated with Amphotericin B and INF-γ.
Conclusion
With respect to the high frequency of aspergillosis in the CGD patient, immune deficiency should be investigated in patients with invasive aspergillosis. Moreover, using antifungal drugs as prophylaxis can improve the quality of life in these patients.