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1:

Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor.

Chen J, Raymond K.

Ann Clin Microbiol Antimicrob. 2006 Feb 15;5:3. Review.

PMID: 16480505 [PubMed - indexed for MEDLINE]

2:

Clinically significant interactions with drugs used in the treatment of tuberculosis.

Yew WW.

Drug Saf. 2002;25(2):111-33. Review.

PMID: 11888353 [PubMed - indexed for MEDLINE]

3:

Inducing properties of rifampicin and rifabutin for selected enzyme activities of the cytochrome P-450 and UDP-glucuronosyltransferase superfamilies in female rat liver.

Oesch F, Arand M, Benedetti MS, Castelli MG, Dostert P.

J Antimicrob Chemother. 1996 Jun;37(6):1111-9.

PMID: 8836814 [PubMed - indexed for MEDLINE]

4:

Pharmacokinetic drug interactions with rifampicin.

Venkatesan K.

Clin Pharmacokinet. 1992 Jan;22(1):47-65. Review.

PMID: 1559307 [PubMed - indexed for MEDLINE]

5:

Molecular mechanisms of cytochrome p450 induction: potential for drug-drug interactions.

Jana S, Paliwal J.

Curr Protein Pept Sci. 2007 Dec;8(6):619-28. Review.

PMID: 18220847 [PubMed - indexed for MEDLINE]

6:

Pharmacokinetic interactions with rifampicin : clinical relevance.

Niemi M, Backman JT, Fromm MF, Neuvonen PJ, Kivistö KT.

Clin Pharmacokinet. 2003;42(9):819-50. Review.

PMID: 12882588 [PubMed - indexed for MEDLINE]

7:

Structure and function of the human nuclear xenobiotic receptor PXR.

Carnahan VE, Redinbo MR.

Curr Drug Metab. 2005 Aug;6(4):357-67. Review.

PMID: 16101574 [PubMed - indexed for MEDLINE]

8:

Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro.

Haughton EL, Tucker SJ, Marek CJ, Durward E, Leel V, Bascal Z, Monaghan T, Koruth M, Collie-Duguid E, Mann DA, Trim JE, Wright MC.

Gastroenterology. 2006 Jul;131(1):194-209.

PMID: 16831602 [PubMed - indexed for MEDLINE]

9:

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.

Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR.

Mol Endocrinol. 2005 May;19(5):1125-34. Epub 2005 Feb 10.

PMID: 15705662 [PubMed - indexed for MEDLINE]

10:

Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor.

Fang HL, Strom SC, Ellis E, Duanmu Z, Fu J, Duniec-Dmuchowski Z, Falany CN, Falany JL, Kocarek TA, Runge-Morris M.

J Pharmacol Exp Ther. 2007 Nov;323(2):586-98. Epub 2007 Aug 8.

PMID: 17687072 [PubMed - indexed for MEDLINE]

11:

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.

Drug Metab Dispos. 2007 Jul;35(7):1032-41. Epub 2007 Mar 28.

PMID: 17392393 [PubMed - indexed for MEDLINE]

12:

In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation.

Bauer B, Yang X, Hartz AM, Olson ER, Zhao R, Kalvass JC, Pollack GM, Miller DS.

Mol Pharmacol. 2006 Oct;70(4):1212-9. Epub 2006 Jul 12.

PMID: 16837625 [PubMed - indexed for MEDLINE]

13:

[The induction of CYP3A regulated by pregnane X receptor and its significance in drug metabolism]

Wang YG, Wang SQ, Gao Y.

Yao Xue Xue Bao. 2006 Jan;41(1):1-6. Review. Chinese. No abstract available.

PMID: 16683519 [PubMed - indexed for MEDLINE]

14:

The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology.

Harmsen S, Meijerman I, Beijnen JH, Schellens JH.

Cancer Treat Rev. 2007 Jun;33(4):369-80. Epub 2007 Apr 23. Review.

PMID: 17451886 [PubMed - indexed for MEDLINE]

15:

Rifaximin is a gut-specific human pregnane X receptor activator.

Ma X, Shah YM, Guo GL, Wang T, Krausz KW, Idle JR, Gonzalez FJ.

J Pharmacol Exp Ther. 2007 Jul;322(1):391-8. Epub 2007 Apr 18.

PMID: 17442842 [PubMed - indexed for MEDLINE]

16:

CYP3A4 and pregnane X receptor humanized mice.

Gonzalez FJ.

J Biochem Mol Toxicol. 2007;21(4):158-62. Review.

PMID: 17936928 [PubMed - indexed for MEDLINE]

17:

MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.

Lamba J, Strom S, Venkataramanan R, Thummel KE, Lin YS, Liu W, Cheng C, Lamba V, Watkins PB, Schuetz E.

Clin Pharmacol Ther. 2006 Apr;79(4):325-38. Epub 2006 Feb 20.

PMID: 16580901 [PubMed - indexed for MEDLINE]

18:

In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin.

Simonsson US, Lindell M, Raffalli-Mathieu F, Lannerbro A, Honkakoski P, Lang MA.

Eur J Clin Invest. 2006 Sep;36(9):647-53.

PMID: 16919048 [PubMed - indexed for MEDLINE]

19:

The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

Ma X, Shah Y, Cheung C, Guo GL, Feigenbaum L, Krausz KW, Idle JR, Gonzalez FJ.

Drug Metab Dispos. 2007 Feb;35(2):194-200. Epub 2006 Nov 8.

PMID: 17093002 [PubMed - indexed for MEDLINE]

20:

Pharmacokinetic interaction between rifampicin and ritonavir-boosted atazanavir in HIV-infected patients.

Mallolas J, Sarasa M, Nomdedeu M, Soriano A, López-Púa Y, Blanco JL, Martínez E, Gatell JM.

HIV Med. 2007 Mar;8(2):131-4.

PMID: 17352770 [PubMed - indexed for MEDLINE]

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