Drug-related Henoch-Schönlein Purpura.
Escudero A, Lucas E, Vidal JB, Sánchez-Guerrero I, Martínez A, Illán F, Ramos J.
Division of Allergy, Rafael Méndez Hospital, Lorca, Spain.
We report the case of a patient with Henoch-Schönlein Purpura related to a treatment with cefuroxime and diclofenac who presented important systemic manifestations including a glomerulonephritis with IgA mesangial deposits. Skin testing with beta lactam antibiotics and diclofenac were negative in immediate and late reaction as well as RAST test to penicillins G and V. No cautious administration of drugs was done because of the illness severity. Although a reaction to diclofenac could not be excluded we thought that the more probably implicated drug was cefuroxime because the patient referred a purpuric rash after the intake of cephradine for a mastitis, ten years ago.
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PMID: 8882757 [PubMed - indexed for MEDLINE]