Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae.
Jacoby GA, Mills DM, Chow N.
Lahey Clinic, Burlington, Mssachusetts 01805, USA. george.a.jacoby@lahey.org
High-level resistance to ertapenem was produced by beta-lactamases of groups 1, 2f, and 3 in a strain of Klebsiella pneumoniae deficient in Omp35 and Omp36. From a wild-type strain producing ACT-1 beta-lactamase, ertapenem-resistant mutants for which the ertapenem MICs were up to 128 microg/ml and expression of outer membrane proteins was diminished could be selected.
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PMID: 15273152 [PubMed - indexed for MEDLINE]PMCID: PMC478483