|
In vitro activity of selected antibacterials against erythromycin-resistant Streptococcus pneumoniae isolates positive for mef(A) |
||||||||
| Year 1 (n = 2,157) |
Year 2 (n = 1,881) |
Year 3 (n = 2,029) |
Year 4 (n = 1,543) |
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|
|
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| Antibacterial |
MIC90 (μg/mL) |
Susceptibility (%) |
MIC90 (μg/mL) |
Susceptibility (%) |
MIC90 (μg/mL) |
Susceptibility (%) |
MIC90 (μg/mL) |
Susceptibility (%) |
|
|
||||||||
| Penicillin |
4 |
12.3 |
4 |
13.0 |
4 |
14.3 |
4 |
19.0 |
| Amoxicillin-clavulanate |
≥ 8 |
71.8 |
4 |
78.8 |
4 |
82.9 |
2 |
90.7 |
| Cefuroxime |
8 |
23.4 |
8 |
28.8 |
8 |
34.4 |
8 |
44.5 |
| Trimethroprim-sulfamethaxazole |
≥ 8 |
12.4 |
≥ 8 |
17.1 |
≥ 8 |
19.0 |
≥ 8 |
27.6 |
| Tetracycline |
≥ 8 |
71.7 |
≥ 8 |
71.4 |
≥ 8 |
76.5 |
≥ 8 |
81.2 |
| Erythromycin |
16 |
0 |
16 |
0 |
16 |
0 |
16 |
0 |
| Azithromycin |
32 |
0 |
32 |
0.2 |
16 |
0 |
32 |
0 |
| Clarithromycin |
16 |
0.1 |
8 |
0.4 |
8 |
0.1 |
16 |
0.1 |
| Levofloxacin |
1 |
99.0 |
1 |
97.7 |
1 |
98.6 |
1 |
98.6 |
| Telithromycin |
1 |
99.1 |
0.5 |
99.9 |
0.5 |
99.9 |
0.5 |
99.9 |
|
MIC, minimal inhibitory concentration. | ||||||||
Jenkins et al. Annals of Clinical Microbiology and Antimicrobials 2008 7:1 doi:10.1186/1476-0711-7-1 |
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