A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-γ

Setareh Mamishi¹ , Kamiar Zomorodian¹^,2 , Farshid Saadat³ , Mohsen Gerami-Shoar¹ , Bita Tarazooie¹^,2 and Seyad Ahmad Siadati¹

¹Department of Infectious Diseases, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran

²Department of Medical Mycology & Parasitology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran

³Department of Immunology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran

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Annals of Clinical Microbiology and Antimicrobials 2005, 4:4doi:10.1186/1476-0711-4-4


Published:	3 March 2005

Abstract

Background

Chronic granulomatous disease (CGD) is a rare disorder of phagocytes in which absence of superoxide and hydrogen peroxide production in phagocytes predisposes patients to bacterial and fungal infections. The most common fungal infections in these patients are caused by Aspergillus species.

Case presentation

Here, we describe Aspergillus osteomyelitis of the ribs and hepatic abscess in a 5-year-old boy. The patient was successfully treated with Amphotericin B and INF-γ.

Conclusion

With respect to the high frequency of aspergillosis in the CGD patient, immune deficiency should be investigated in patients with invasive aspergillosis. Moreover, using antifungal drugs as prophylaxis can improve the quality of life in these patients.