Hypersensitivity vasculitis induced by cefoperazone/sulbactam

Ismail Islek¹ , Sancar Baris² , Ali O Katranci³ , Ender Ariturk³ and Nuran Gurses¹

¹Department of Pediatrics, Ondokuz Mayis University, School of Medicine, Samsun, Turkey

²Department of Pathology, Ondokuz Mayis University, School of Medicine, Samsun, Turkey

³Department of Pediatric Surgery, Ondokuz Mayis University, School of Medicine, Samsun, Turkey

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Annals of Clinical Microbiology and Antimicrobials 2003, 2:1doi:10.1186/1476-0711-2-1


Published:	3 January 2003

Abstract

Background

Cefoperazone has not been reported to cause vasculitic complications before. Here, we report a case of hypersensitivity vasculitis associated with cefoperazone/sulbactam.

Case presentation

A 13-year-old girl with appendicitis developed hypersensitivity vasculitis on the fifth day of cefoperazone/sulbactam therapy. Hypersensitivity vasculitis resolved gradually after removal of the agent on the seventh day and did not recur. Although hypersensitivity vasculitis has multiple causes, coexistence of hypersensitivity vasculitis and cefoperazone treatment, and the quite resolution of the disease after removal of the drug, strongly favours a causative relationship.

Conclusion

To our knowledge, this is the first report of a hypersensitivity vasculitis associated with cefoperazone.